HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-aminobenzoate → 2-(3-(Ethoxycarbonyl)phenylamino)-2-(6-methoxypyridin-3-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-aminobenzoate | HCID 11400 | — |
| Reactant | (6-Methoxypyridin-3-yl)boronic acid | HCID 2734368 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(3-(Ethoxycarbonyl)phenylamino)-2-(6-methoxypyridin-3-yl)acetic acid | HCID 58556988 | 38% |
Reaction Steps
A mixture of 6-methoxypyridin-3-ylboronic acid (1.2 g, 7.84 mmol), ethyl 3-aminobenzoate (1.29 g, 7.84 mmol), and 2-oxoacetic acid hydrate (723 mg, 7.84 mmol) in acetonitrile (70 ml) was stirred at room temperature overnight. The solvent was evaporated under vacuum, and the crude product was purified by flash chromatography (DCM/MeOH=9/1) to obtain 2-(3-(ethoxycarbonyl)phenylamino)-2-(6-methoxypyridin-3-yl)acetic acid (0.95 g, 38% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629160B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-8369962b561541e08ea1fbba3ee7323d |
| Source note | uspto-grants-2014_01 |