racemic (R,S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate → (R,S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate

Participants

Reaction Steps

Sufficient racemic (R,S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate is dissolved in isopropanol to form a 52.6% by weight (R,S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate solution. The solution is seeded at 20° C. with about 1%, relative to the weight of the solution, of (S)-acetate and is stirred at 0° C. for 2 to 3 hours. The crystallized (S)-acetate is filtered off with suction and washed with tert.-butyl methyl ether.

Provenance & Evidence