2-Chloroacetophenone → HCID 86660338, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (143 mg, 0.93 mmol) was added to a solution of (R)-quinuclidin-3-yl 2-(3-ethylphenylamino)-2-(6-methoxypyridin-3-yl)acetate (C74) (366 mg, 0.93 mmol) in EtOAc (3 ml), and the resulting reaction was stirred at room temperature overnight. The solvent was evaporated, and the crude product was purified by preparative HPLC (Eluent: CH3CN/H2O) to obtain (3R)-3-(2-(3-ethylphenylamino)-2-(6-methoxypyridin-3-yl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (69.3 mg, 13.6% yield over two steps).

Provenance & Evidence