3-Fluoroaniline → HCID 58557019, compound

Participants

Reaction Steps

A mixture of 6-methoxypyridin-3-ylboronic acid (200 mg, 1.31 mmol), 3-fluoroaniline (126 μl, 1.31 mmol) and 2-oxoacetic acid hydrate (120 mg, 1.31 mmol) in acetonitrile (20 ml) was stirred at room temperature overnight. The solvent was evaporated, and the crude product was purified by flash-chromatography (DCM/MeOH=9/1) to obtain 2-(3-fluorophenylamino)-2-(6-methoxypyridin-3-yl)acetic acid (48 mg, 13.3% yield).

Provenance & Evidence