4-(4-Bromophenyl)phthalazin-1(2h)-one → HCID 67161042, compound

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Reaction Steps

A mixture of 4-(4-bromophenyl)phthalazin-1(2H)-one (Aldrich) (0.200 g, 0.663 mmol) and KOtBu (1 M in THF, 1.0 mL, 1.0 mmol) in THF (2 mL) was stirred for 45 minutes, diluted with DMF (1 mL), and O-(diphenylphosphoryl)hydroxylamine (0.240 g, 1.03 mmol) was added and stirred for 90 minutes. The mixture was diluted with EtOAc, washed with saturated aqueous NaHCO3 and brine, dried (Na2SO4), and concentrated to give 302 mg of crude material as a white solid, which was used without purification. LC/MS (APCI) M/Z 318.0 (M+H)+.

Provenance & Evidence