O-(Diphenylphosphinyl)hydroxylamine → HCID 67160981, compound

Participants

Reaction Steps

A mixture of Example 8B (31.5 mg, 0.144 mmol) and KOtBu (1 M in THF, 0.16 mL, 0.16 mmol) in THF (0.3 mL) and DMF (0.2 mL) was stirred for 30 minutes, and O-(diphenylphosphoryl)hydroxylamine (37.0 mg, 0.159 mmol) was added and stirred 4 h. The mixture was diluted with EtOAc, washed with saturated aqueous NaHCO3 and brine, dried (Na2SO4), and filtered. The residue was chromatographed on SiO2 (2.5% MeOH/CH2Cl2) to give the title compound as a white solid (18.3 mg) which was used without further purification. LC/MS (APCI) M/Z 234.2 (M+H)+.

Provenance & Evidence