Triethylamine → HCID 67161288, compound

Participants

Reaction Steps

A mixture of the product of Example 9B (31.6 mg, 0.13 mmol), triethylamine (0.028 mL, 0.20 mmol), 2-(3,5-difluorophenyl)acetic acid (25.4 mg, 0.15 mmol), and O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (49.8 mg, 0.16 mmol) in DMF (0.4 mL) was stirred overnight, diluted with EtOAc, washed with 1 N NaOH and brine, dried (Na2SO4), and filtered. The residue was chromatographed on SiO2 (12% EtOAc/CH2Cl2) to give the title compound as a white solid (6.2 mg, 0.016 mmol). 1H NMR (300 MHz, DMSO-d6) δ 11.80 (s, 1H), 8.24 (d, J=5.2 Hz, 1H), 7.87-7.77 (m, 3H), 7.64-7.55 (m, 3H), 7.22-7.08 (m, 3H), 3.78 (s, 2H); MS (ESI−) M/Z 396.1 (M−H)−.

Provenance & Evidence