Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-(Diphenylphosphinyl)hydroxylamine → 2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-(Diphenylphosphinyl)hydroxylamine | HCID 10955453 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 반응물 | 1(2H)-Phthalazinone, 4-(trifluoromethyl)- | HCID 67161347 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one | HCID 67161111 | — |
반응 단계
A mixture of Example 11A and KOtBu (1 M in THF, 2.8 mL, 2.8 mmol) in THF (5 mL) was stirred for 60 min, and O-(diphenylphosphoryl)hydroxylamine (0.680 mg, 0.348 mmol) was added and stirred for 1 hour. The mixture was diluted with EtOAc, washed with 1 N NaOH and water, dried (Na2SO4), and concentrated to give the title compound as a white solid (402 mg) which was used without purification. 1H NMR (300 MHz, DMSO-d6) δ 8.45-8.35 (m, 1H), 8.10-7.92 (m, 3H), 6.58 (s, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08629143B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-99f8592b3930448e8aa8d3f4f9ddb96f |
| 출처 메모 | uspto-grants-2014_01 |