HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2-amino-4-phenylphthalazin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-Phenyl-1-(2H)-phthalazinone | HCID 219150 | — |
| Reactant | O-(Diphenylphosphinyl)hydroxylamine | HCID 10955453 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-amino-4-phenylphthalazin-1(2H)-one | HCID 21262537 | 95% |
Reaction Steps
A mixture of 4-phenylphthalazin-1(2H)-one (Aldrich) (500 mg, 2.25 mmol) and KOtBu (3.37 mL, 3.37 mmol) was stirred for 45 minutes, diluted with DMF for solubility, and Example 17A (787 mg, 3.37 mmol) was added and stirred for 3 hours. The mixture was diluted with EtOAc, washed with saturated NaHCO3 and brine, dried (Na2SO4), filtered, and concentrated to give 509 mg (95%) of the title compound. MS (DCI/NH3) m/z 238 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629143B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-8c387b1a38c74ff5b40ca8df2d698c73 |
| Source note | uspto-grants-2014_01 |