(4-Chlorophenyl)acetic acid → HCID 53237738, compound

HRID 469537Notes

Reaction equation

HRID 469537 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([Cl:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:13].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22](O)=[O:23])=[CH:17][CH:16]=1>>[Cl:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:13])[N:2]([NH:1][C:22](=[O:23])[CH2:21][C:18]2[CH:19]=[CH:20][C:15]([Cl:14])=[CH:16][CH:17]=2)[N:11]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67160580HCID 67160580, compound

Product 1

HCID 53237738HCID 53237738, compound

Procedure

The product from Example 19A and 2-(4-chlorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.70 (s, 2H) 7.23-7.56 (m, 4H) 7.97-8.17 (m, 3H) 8.36 (d, J=7.63 Hz, 1H) 11.77 (s, 1H); MS (ESI) m/z 349 (M+H)+.

Sources & evidence

ORD record
ord-6346f382723445c2810814356c66ab09
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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