3,5-Difluorophenylacetic acid → 2-(3,5-difluorophenyl)-N-(7-oxo-4-phenylthieno[2,3-d]pyridazin-6(7H)-yl)acetamide

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Reaction Steps

The product from Example 29B and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.79 (s, 2H) 6.94-7.36 (m, 3H) 7.51-7.64 (m, 4H) 7.61-7.84 (m, 2H) 8.37 (d, J=5.19 Hz, 1H) 11.87 (s, 1H); MS (ESI) m/z 398 (M+H)+.

Provenance & Evidence