2-(3,5-Dimethyladamantan-1-yl)acetic acid → 2-[3,5-dimethyl-1-adamantyl]-N-(4-isopropyl-1-oxophthalazin-2(1H)-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(3,5-Dimethyladamantan-1-yl)acetic acid	HCID 4067589	—
Reactant	2-amino-4-isopropylphthalazin-1(2H)-one	HCID 67161646	—
Product	2-[3,5-dimethyl-1-adamantyl]-N-(4-isopropyl-1-oxophthalazin-2(1H)-yl)acetamide	HCID 53237965	—

Reaction Steps

The product from Example 1B and 2-(3,5-dimethyl-1-adamantyl)acetic acid were processed using the method described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 0.81 (s, 6H) 0.98-1.20 (m, 2H) 1.20-1.42 (m, 14H) 1.52 (s, 2H) 1.98-2.14 (m, 3H) 3.49-3.73 (m, 1H) 7.89 (t, J=7.48 Hz, 1H) 7.95-8.04 (m, 1H) 8.11 (d, J=8.24 Hz, 1H) 8.34 (d, J=6.71 Hz, 1H) 11.12 (s, 1H); MS (ESI) m/z 408 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08629143B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-959adbca2a5c4868b911760aa7df0ec7
Source note	uspto-grants-2014_01