(4-Chlorophenyl)acetic acid → HCID 53237967, compound

HRID 469553Notes

Reaction equation

HRID 469553 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([F:18])[CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](O)=[O:29])=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([F:18])[CH:8]=3)[C:3]2=[O:19])=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67161481HCID 67161481, compound

Product 1

HCID 53237967HCID 53237967, compound

Procedure

The product from Example 35E and 4-chlorophenylacetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.70 (s, 2H) 7.28-7.52 (m, 5H) 7.50-7.70 (m, 5H) 7.72-7.99 (m, 1H) 8.47 (dd, J=8.85, 5.49 Hz, 1H) 11.62-11.89 (m, 1H); MS (ESI) m/z 408 (M+H)+.

Sources & evidence

ORD record
ord-6db4d352d54f4b24819905e0d5c94045
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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