HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthaleneacetic acid → 2-(2-naphthyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthaleneacetic acid | HCID 11393 | — |
| Reactant | 2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one | HCID 67161111 | — |
| Product | 2-(2-naphthyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide | HCID 53238202 | — |
Reaction Steps
The product of Example 11B and 2-napthylacetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.44 (ddd, J=8.0, 1.4, 0.6 Hz, 1H), 8.12-8.16 (m, 1H), 8.01-8.09 (m, 2H), 7.87-7.97 (m, 4H), 7.48-7.59 (m, 3H), 3.91 (s, 2H); MS (ESI−) M/Z 396 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629143B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-859b4fc87a3743349e0571f03f9f4eba |
| Source note | uspto-grants-2014_01 |