HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoro-2-phenylacetic acid → 2,2-difluoro-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]-2-phenylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoro-2-phenylacetic acid | HCID 726153 | — |
| Reactant | 2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one | HCID 67161111 | — |
| Product | 2,2-difluoro-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]-2-phenylacetamide | HCID 53238430 | — |
Reaction Steps
The product of Example 11B and 2,2-difluoro-2-phenylacetic acid were treated using a method similar to that described in Example 51 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 13.10 (s, 1H), 8.43-8.47 (m, 1H), 8.16 (td, J=7.6, 1.6 Hz, 1H), 8.03-8.12 (m, 2H), 7.74-7.78 (m, 2H), 7.54-7.66 (m, 3H); MS (ESI+) M/Z 384 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629143B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-ed83ae45cd824ec2b97ec1a3555b825e |
| Source note | uspto-grants-2014_01 |