beta-Phenylisovaleric acid → HCID 67159864, compound

HRID 469577Notes

Reaction equation

HRID 469577 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[CH3:17][C:18]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([CH3:23])[CH2:19][C:20](O)=[O:21]>>[C:12]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:16])[N:2]([NH:1][C:20](=[O:21])[CH2:19][C:18]([CH3:17])([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH3:23])[N:11]=1)([CH3:13])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 13890beta-Phenylisovaleric acidHCID 67161087HCID 67161087, compound

Product 1

HCID 67159864HCID 67159864, compound

Procedure

The product from Example 62A and 3-methyl-3-phenylbutanoic acid were treated using a method similar to that described in Example 51 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.21 (s, 1H), 8.35-8.39 (m, 2H), 7.93-7.99 (m, 1H), 7.84-7.90 (m, 1H), 7.43-7.47 (m, 2H), 7.24-7.39 (m, 2H), 7.15-7.21 (m, 1H), 2.59 (s, 2H), 1.47 (s, 6H), 1.46 (s, 9H); MS (ESI−) M/Z 376 (M−H)−.

Sources & evidence

ORD record
ord-411231b8aaaa4a8b8b4d02d019103c3e
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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