(4-Chlorophenyl)acetic acid → HCID 67160704, compound

HRID 469581Notes

Reaction equation

HRID 469581 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH:12]2[CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](O)=[O:26])=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25]([NH:1][N:2]2[N:11]=[C:10]([CH:12]3[CH2:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:16])=[O:26])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67162274HCID 67162274, compound

Product 1

HCID 67160704HCID 67160704, compound

Procedure

The product of Example 67A and 2-(4-chlorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.57 (s, 1H), 8.31 (d, J=8.3 Hz, 1H), 7.83-8.03 (m, 3H), 7.42 (s, 4H), 4.05 (p, J=8.5 Hz, 1H), 3.70 (s, 2H), 2.21-2.44 (m, 4H), 2.02-2.14 (m, 1H), 1.78-1.87 (m, 1H); MS (ESI) m/z 368 (M+H)+.

Sources & evidence

ORD record
ord-dba5d061a40f45f089deee0a94cb688f
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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