1-Adamantaneacetyl chloride → HCID 67160092, compound

Participants

Reaction Steps

The product of Example 74A and 2-(adamantan-1-yl)acetyl chloride were processed using a method similar to that described in Example 1C, and purified by preparative HPLC [Phenomenex Luna C8(2) 5 um 100 Å AXIA column (30 mm×75 mm); a gradient of acetonitrile (A) and 0.1% trifluoroacetic acid in water (B) was used, at a flow rate of 50 mL/min (0-0.5 min 10% A, 0.5-7.0 min linear gradient 10-95% A, 7.0-10.0 min 95% A, 10.0-12.0 min linear gradient 95-10% A)] to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.10 (s, 1H), 8.34 (d, J=7.9 Hz, 1H), 8.11 (d, J=8.1 Hz, 1H), 7.97-8.01 (m, 1H), 7.89 (t, J=7.5 Hz, 1H), 3.21-3.40 (m, 1H), 1.39-1.98 (m, 26H), 1.13-1.27 (m, 1H); MS (ESI) m/z 420 (M+H)+.

Provenance & Evidence