beta-Phenylisovaleric acid → N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-3-methyl-3-phenylbutanamide

Participants

Role	Name	HCID	Charge
Reactant	beta-Phenylisovaleric acid	HCID 13890	—
Reactant	2-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one	HCID 67161367	—
Product	N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-3-methyl-3-phenylbutanamide	HCID 53239543	—

Reaction Steps

The product of Example 86A and 3-methyl-3-phenylbutanoic acid were treated as in Example 51 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.39 (s, 1H), 8.39-8.44 (m, 1H), 7.88-8.02 (m, 2H), 7.70-7.77 (m, 1H), 7.63-7.67 (m, 2H), 7.60-7.63 (m, 2H), 7.42-7.46 (m, 2H), 7.28-7.34 (m, 2H), 7.15-7.21 (m, 1H), 2.62 (s, 2H), 1.47 (s, 6H); MS (APCI+) M/Z 432 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08629143B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-c64423146f304bfd9d2ec016f5545544
Source note	uspto-grants-2014_01