2-(Morpholin-4-yl)acetic acid hydrochloride → HCID 53239328, compound

HRID 469593Notes

Reaction equation

HRID 469593 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].Cl.[O:21]1[CH2:26][CH2:25][N:24]([CH2:27][C:28](O)=[O:29])[CH2:23][CH2:22]1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:28](=[O:29])[CH2:27][N:24]3[CH2:25][CH2:26][O:21][CH2:22][CH2:23]3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 177509462-(Morpholin-4-yl)acetic acid hydrochlorideHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53239328HCID 53239328, compound

Procedure

The product of Example 86A and 2-morpholinoacetic acid hydrochloride were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.42-8.46 (m, 1H), 7.96-8.08 (m, 2H), 7.75-7.79 (m, 1H), 7.64-7.69 (m, 4H), 4.27-4.28 (m, 2H), 3.79-3.94 (m, 4H), 3.34-3.38 (m, 4H); MS (APCI+) M/Z 399 (M+H)+.

Sources & evidence

ORD record
ord-7942809b2ceb4762b0bb53da234461b1
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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