HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridineacetic acid, hydrochloride (1:1) → N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(pyridin-3-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridineacetic acid, hydrochloride (1:1) | HCID 2723724 | — |
| Reactant | 2-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one | HCID 67161367 | — |
| Product | N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(pyridin-3-yl)acetamide | HCID 53239325 | — |
Reaction Steps
The product of Example 86A and 2-(pyridin-3-yl)acetic acid hydrochloride were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.83-8.84 (bs, 1H), 8.75 (d, J=5.5 Hz, 1H), 8.36-8.50 (m, 2H), 7.96-8.02 (m, 2H), 7.92 (dd, J=8.0, 5.5 Hz, 1H), 7.73-7.75 (m, 1H), 7.59-7.70 (m, 4H), 4.00 (s, 2H); MS (APCI+) M/Z 391 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629143B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-9862af7429b04ecc937627e1c457a4d4 |
| Source note | uspto-grants-2014_01 |