3,4-Dichlorophenylacetic acid → HCID 53239326, compound

HRID 469596Notes

Reaction equation

HRID 469596 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29](O)=[O:30])[CH:24]=[CH:25][C:26]=1[Cl:27]>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:23]3[CH:24]=[CH:25][C:26]([Cl:27])=[C:21]([Cl:20])[CH:22]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53239326HCID 53239326, compound

Procedure

The product of Example 86A and 2-(3,4-dichlorophenyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.43 (m, 1H), 7.90-8.04 (m, 2H), 7.72-7.75 (m, 1H), 7.58-7.70 (m, 6H), 7.38 (dd, J=8.3, 2.1 Hz, 1H), 3.75 (s, 2H); MS (ESI−) M/Z 456 (M−H)−.

Sources & evidence

ORD record
ord-d45b95d1332640b3b2fcfb83d7fc65b0
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

Loading…