HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethoxy)phenylacetic Acid → N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethoxy)phenylacetic Acid | HCID 2777316 | — |
| Reactant | 2-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one | HCID 67161367 | — |
| Product | N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide | HCID 53239110 | — |
Reaction Steps
The product of Example 86A and 2-[3-(trifluoromethoxy)phenyl]acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.41-8.43 (m, 1H), 7.95-8.02 (m, 2H), 7.73-7.75 (m, 1H), 7.63-7.64 (m, 4H), 7.50 (t, J=7.9 Hz, 1H), 7.42 (d, J=7.8 Hz, 1H), 7.38-7.40 (bs, 1H), 7.27-7.30 (m, 1H), 3.79 (s, 2H); MS (ESI−) M/Z 472 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629143B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-417c220d20904b639888f5e369a7ae30 |
| Source note | uspto-grants-2014_01 |