3-Chlorophenylacetic acid → HCID 53238893, compound

HRID 469604Notes

Reaction equation

HRID 469604 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:22]=[C:23]([CH2:27][C:28](O)=[O:29])[CH:24]=[CH:25][CH:26]=1>>[Cl:20][C:21]1[CH:22]=[C:23]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:29])[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 158793-Chlorophenylacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53238893HCID 53238893, compound

Procedure

The product of Example 86A and 2-(3-chlorophenyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.41-8.43 (m, 1H), 7.93-8.04 (m, 2H), 7.72-7.75 (m, 1H), 7.62-7.66 (m, 4H), 7.47 (t, J=1.8 Hz, 1H), 7.31-7.42 (m, 3H), 3.74 (s, 2H); MS (ESI−) M/Z 422 (M−H)−.

Sources & evidence

ORD record
ord-3b2146812338438689ad0ce7e1e66871
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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