(3-Methoxyphenyl)acetic acid → HCID 53238891, compound

HRID 469606Notes

Reaction equation

HRID 469606 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH2:28][C:29](O)=[O:30])[CH:25]=[CH:26][CH:27]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([O:21][CH3:20])[CH:23]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 15719(3-Methoxyphenyl)acetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53238891HCID 53238891, compound

Procedure

The product of Example 86A and 2-(3-methoxyphenyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.41-8.43 (m, 1H), 7.96-8.01 (m, 2H), 7.72-7.74 (m, 1H), 7.60-7.67 (m, 4H), 7.27 (t, J=7.9 Hz, 1H), 6.98 (d, J=2.4 Hz, 1H), 6.96 (d, J=7.6 Hz, 1H), 6.85 (dd, J=8.2, 2.6 Hz, 1H), 3.76 (s, 3H), 3.67-3.67 (bs, 2H; MS (ESI−) M/Z 418 (M−H)−.

Sources & evidence

ORD record
ord-8410d7139fd64ca58eba93276cf804f8
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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