HCID 58127025, compound → HCID 67160927, compound

HRID 469614Notes

Reaction equation

HRID 469614 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](Cl)=[O:29])=[CH:23][C:22]=1[F:31]>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:29])=[CH:23][C:22]=1[F:31]

Participants

3

Reactant 2

HCID 58127025HCID 58127025, compoundHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 67160927HCID 67160927, compound

Procedure

The product from Example 86A and 2-(4-chloro-3-fluorophenyl)acetyl chloride were treated using a method similar to that described in Example 1C to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.70-11.79 (m, 1H), 8.39-8.44 (m, 1H), 7.88-8.05 (m, 2H), 7.71-7.76 (m, 1H), 7.63 (s, 4H), 7.57 (t, J=8.1 Hz, 1H), 7.44 (dd, J=10.5, 1.9 Hz, 1H), 7.25 (dd, J=8.3, 1.9 Hz, 1H), 3.75 (s, 2H); MS (ESI+) M/Z 442 (M+H)+.

Sources & evidence

ORD record
ord-eafdb611662e43799883a28de6c7f6bb
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

Loading…