2-Naphthaleneacetic acid → HCID 67160925, compound

HRID 469620Notes

Reaction equation

HRID 469620 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[CH:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][C:21]=1[CH2:30][C:31](O)=[O:32]>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:31](=[O:32])[CH2:30][C:21]3[CH:22]=[CH:23][C:24]4[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH:20]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 113932-Naphthaleneacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 67160925HCID 67160925, compound

Procedure

The product from Example 86A and 2-(2-naphthyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.41-8.43 (m, 1H), 7.96-8.04 (m, 2H), 7.86-7.94 (m, 4H), 7.72-7.75 (m, 1H), 7.61-7.66 (m, 4H), 7.50-7.57 (m, 3H), 3.88 (s, 2H); MS (APCI+) M/Z 440 (M+H)+.

Sources & evidence

ORD record
ord-0fc3ba4177ed4c97bd8406403a4a99a0
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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