1-Adamantaneacetic acid → HCID 67161327, compound

HRID 469623Notes

Reaction equation

HRID 469623 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[C:20]12([CH2:30][C:31](O)=[O:32])[CH2:29][CH:24]3[CH2:25][CH:26]([CH2:28][CH:22]([CH2:23]3)[CH2:21]1)[CH2:27]2>>[C:20]12([CH2:30][C:31]([NH:1][N:2]3[N:11]=[C:10]([C:12]4[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=4)[C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[C:3]3=[O:19])=[O:32])[CH2:27][CH:26]3[CH2:25][CH:24]([CH2:23][CH:22]([CH2:28]3)[CH2:21]1)[CH2:29]2

Participants

3

Reactant 2

HCID 1232211-Adamantaneacetic acidHCID 67160366HCID 67160366, compound

Product 1

HCID 67161327HCID 67161327, compound

Procedure

The product of Example 125A and 2-(adamantan-1-yl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO) δ 11.29 (s, 1H), 8.46-8.39 (m, 1H), 8.02-7.92 (m, 2H), 7.76-7.69 (m, 1H), 7.68-7.54 (m, 4H), 2.06 (s, 2H), 1.95 (s, 3H), 1.74-1.51 (m, 12H); MS (APCI) m/z 448 (M+H)+.

Sources & evidence

ORD record
ord-7864aef7f7c543a595cfdb2ba534fb52
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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