(4-Chlorophenyl)acetic acid → 2-(4-chlorophenyl)-N-[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	(4-Chlorophenyl)acetic acid	HCID 15880	—
Reactant	2-amino-4-(4-methylphenyl)-phthalazin-1(2H)-one	HCID 67162325	—
Product	2-(4-chlorophenyl)-N-[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetamide	HCID 67160564	—

Reaction Steps

The product of Example 135A and 2-(4-chlorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.71 (s, 1H), 8.38-8.41 (m, 1H), 7.89-8.02 (m, 2H), 7.72-7.75 (m, 1H), 7.46-7.49 (m, 2H), 7.38-7.44 (m, 4H), 7.36-7.40 (m, 2H), 3.70 (s, 2H), 2.41 (s, 3H); MS (APCI+) M/Z 404 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08629143B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-1e46999b404f4ef2a92c110030e7f683
Source note	uspto-grants-2014_01