3,5-Difluorophenylacetic acid → 2-(3,5-difluorophenyl)-N-[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	3,5-Difluorophenylacetic acid	HCID 145424	—
Reactant	2-amino-4-(4-methylphenyl)-phthalazin-1(2H)-one	HCID 67162325	—
Product	2-(3,5-difluorophenyl)-N-[4-(4-methylphenyl)-1-oxophthalazin-2(1H)-yl]acetamide	HCID 53236624	—

Reaction Steps

The product of Example 135A and 2-(3,5-difluorophenyl)acetic acid were treated as in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.75 (s, 1H), 8.39-8.42 (m, 1H), 7.89-8.03 (m, 2H), 7.73-7.76 (m, 1H), 7.47-7.50 (m, 2H), 7.37-7.40 (m, 2H), 7.09-7.22 (m, 3H), 3.77 (s, 2H), 2.42 (s, 3H); MS (APCI+) M/Z 406 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08629143B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-e2348512fdd0426db06bb5293ec3bffb
Source note	uspto-grants-2014_01