(4-Chlorophenyl)acetic acid → HCID 67161170, compound

HRID 469635Notes

Reaction equation

HRID 469635 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](O)=[O:29])=[CH:23][CH:22]=1>>[CH2:12]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:19])[N:2]([NH:1][C:28](=[O:29])[CH2:27][C:24]2[CH:25]=[CH:26][C:21]([Cl:20])=[CH:22][CH:23]=2)[N:11]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67160562HCID 67160562, compound

Product 1

HCID 67161170HCID 67161170, compound

Procedure

The product of Example 139A and 2-(4-chlorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.64 (s, 1H), 8.30 (dd, J=7.8, 1.5 Hz, 1H), 7.96-7.99 (m, 1H), 7.91 (ddd, J=8.0, 7.2, 1.5 Hz, 1H), 7.85 (ddd, J=7.8, 7.2, 1.4 Hz, 1H), 7.35-7.47 (m, 4H), 7.25-7.33 (m, 4H), 7.16-7.23 (m, 1H), 4.31-4.32 (bs, 2H), 3.71 (s, 2H); LC/MS (APCI) M/Z 404 (M+H)+.

Sources & evidence

ORD record
ord-ea628f9490fd438ab01fe34a22dfa613
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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