3,5-Difluorophenylacetic acid → HCID 67162361, compound

HRID 469636Notes

Reaction equation

HRID 469636 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[F:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29](O)=[O:30])[CH:24]=[C:25]([F:27])[CH:26]=1>>[CH2:12]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:19])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:23]2[CH:22]=[C:21]([F:20])[CH:26]=[C:25]([F:27])[CH:24]=2)[N:11]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67160562HCID 67160562, compound

Product 1

HCID 67162361HCID 67162361, compound

Procedure

The product of Example 139A and 2-(3,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.66-11.72 (bs, 1H), 8.32 (dd, J=7.8, 1.5 Hz, 1H), 7.97-8.00 (m, 1H), 7.92 (ddd, J=8.0, 7.2, 1.5 Hz, 1H), 7.86 (ddd, J=7.8, 7.1, 1.3 Hz, 1H), 7.24-7.37 (m, 4H), 7.11-7.23 (m, 4H), 4.32-4.32 (bs, 2H), 3.77 (s, 2H); LC/MS (APCI) M/Z 406 (M+H)+.

Sources & evidence

ORD record
ord-e17f78a1765743be822c4347569eda93
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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