(4-Chlorophenyl)acetic acid → HCID 53236623, compound

HRID 469657Notes

Reaction equation

HRID 469657 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:21].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30](O)=[O:31])=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([CH:18]([CH3:19])[CH3:20])=[CH:16][CH:17]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:21])=[O:31])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67160201HCID 67160201, compound

Product 1

HCID 53236623HCID 53236623, compound

Procedure

The product of Example 168A and 2-(4-chlorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.69-11.71 (bs, 1H), 8.38-8.41 (m, 1H), 7.89-8.03 (m, 2H), 7.75-7.77 (m, 1H), 7.50-7.53 (m, 2H), 7.42-7.46 (m, 2H), 7.37-7.43 (m, 4H), 3.70 (s, 2H), 2.93-3.06 (m, 1H), 1.27 (d, J=6.9 Hz, 6H); MS (APCI+) M/Z 432 (M+H)+.

Sources & evidence

ORD record
ord-b98ef73da28742149a9909ef84003654
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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