2-(3-Bromoadamantan-1-yl)acetic acid → 2-(3-bromoadamantan-1-yl)-N-(7-oxo-4-phenylthieno[2,3-d]pyridazin-6(7H)-yl)acetamide

Participants

Reaction Steps

The product from Example 29B and 2-(3-bromoadamantan-1-yl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 11.47 (s, 1H), 8.36 (d, J=5.2 Hz, 1H), 7.71-7.73 (m, 2H), 7.56-7.59 (m, 4H), 2.32-2.34 (m, 2H), 2.27-2.32 (m, 2H), 2.19-2.25 (m, 2H), 2.17 (s, 2H), 2.12-2.16 (m, 2H), 1.62-1.75 (m, 5H), 1.56-1.60 (m, 1H); MS (APCI+) M/Z 498 (M+H)+.

Provenance & Evidence