3,5-Difluorophenylacetic acid → HCID 67161262, compound

HRID 469671Notes

Reaction equation

HRID 469671 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[C:3]1=[O:18].[F:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28](O)=[O:29])[CH:23]=[C:24]([F:26])[CH:25]=1>>[F:19][C:20]1[CH:21]=[C:22]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:9]3[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=3[C:3]2=[O:18])=[O:29])[CH:23]=[C:24]([F:26])[CH:25]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67160016HCID 67160016, compound

Product 1

HCID 67161262HCID 67161262, compound

Procedure

The product from Example 185A and 2-(3,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.68-11.71 (bs, 1H), 7.39-7.51 (m, 5H), 7.04-7.20 (m, 3H), 3.72 (s, 2H), 2.51-2.55 (m, 2H), 2.37-2.41 (m, 2H), 1.69-1.77 (m, 2H), 1.58-1.65 (m, 2H); MS (APCI+) M/Z 396 (M+H)+.

Sources & evidence

ORD record
ord-9698a5cec0e04037ae2bc1722093d6f7
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

Loading…