(4-Chlorophenyl)acetic acid → HCID 67160097, compound

HRID 469672Notes

Reaction equation

HRID 469672 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[C:3]1=[O:18].[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:9]3[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=3[C:3]2=[O:18])=[O:28])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67160016HCID 67160016, compound

Product 1

HCID 67160097HCID 67160097, compound

Procedure

The product from Example 185A and 2-(4-chlorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.64 (s, 1H), 7.29-7.51 (m, 9H), 3.65 (s, 2H), 2.50-2.55 (m, 2H), 2.36-2.40 (m, 2H), 1.68-1.76 (m, 2H), 1.57-1.65 (m, 2H); MS (APCI+) M/Z 394 (M+H)+.

Sources & evidence

ORD record
ord-6b0bd8c57c6d46ebb5a3e59f843fefbe
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

Loading…