5-Bromo-2-(trifluoromethyl)pyridine → HCID 57514758, compound

HRID 469679Notes

Reaction equation

HRID 469679 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7](B2OC(C)(C)C(C)(C)O2)[CH:6]=[CH:5][N:4]=1.Br[C:19]1[CH:20]=[CH:21][C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][CH:24]=1>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:19]2[CH:24]=[N:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)[CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 27611975-Bromo-2-(trifluoromethyl)pyridineHCID 447548622-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Product 1

HCID 57514758HCID 57514758, compoundYield 816.4%

Procedure

2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1.24 g, 0.53 mmol) and 5-bromo-2-(trifluoromethyl)pyridine (2.4 g, 11 mmol) were reacted according to the procedure of Example 3 (step a) to provide the title compound (1.1 g, 81%) as a white solid: ESI MS m/z 255 [M+H].

Sources & evidence

ORD record
ord-fa88d8aff54242a3b180877d4940b5fc
Source dataset
uspto-grants-2014_01
Patent number
US08629158B2

Reaction notes

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