Trifluoroacetic acid → HCID 178522352, compound

Participants

Reaction Steps

To a flask containing N-(2,2-dimethoxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2-hydroxyquinoline-3-carboxamide (65 mg, 0.18 mmol) was added trifluoroacetic acid (15 mL) in one portion. The solution was stirred 3 hours, after which the reaction was judged complete by LC-MS. The trifluoroacetic acid was removed in vacuo and the product dried with a stream of nitrogen to afford 57 mg (100%) of the title product that contained ca. 15% of a byproduct that was suggested to be the hydrolyzed product (at both amide and epoxide positions; M+ 204). The solid was used in the next step without additional characterization or purification.

Provenance & Evidence