Hydrochloric Acid → HCID 67953856, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-pyrrolidine-2-carboxylic acid (3-tert-butyl-isoxazol-5-yl)-amide; hydrochloride (0.2 g; 0.731 mmol) in N,N-dimethylformamide (4 mL) is added bromomethyl-cyclohexane (0.153 mL; 1.097 mmol), potassium iodide (0.032 mg, 0.197 mmoL), and potassium carbonate (0.505 g; 3.655 mmol). The mixture heated at 60° C. for 7 days. After this time, the mixture is cooled to room temperature, diluted with water and extracted with ethyl acetate. The combined organics are washed with water, 1N hydrochloric acid and brine, dried (Na2SO4), filtered and concentrated in vacuo. The crude material is purified by preparative reverse phase HPLC to afford title compound. ESI m/z 334 [M+H]+

Provenance & Evidence