Water → HCID 67460966, compound

Participants

Reaction Steps

To a solution of 3-[(S)-2-(5-tert-butyl-isoxazol-3-ylcarbamoyl)-5-oxo-pyrrolidin-1-yl]-benzoic acid methyl ester (870 mg, 2.23 mmol) in methanol (30 mL) a 2 M solution of sodium hydroxide in water (5 mL, 10 mmol) is added at room temperature. After 18 h solvent is evaporated in vacuo, the concentrate is cooled in an ice-bath and acidified to pH 2 using 1 N sulfuric acid. Precipitated white solid is filtered, washed with water and dried to give the title compound, ESI m/z 372 [M+H]+.

Provenance & Evidence