Trifluoroacetic acid → HCID 67953243, compound

Participants

Reaction Steps

A solution of {4-[(S)-2-(5-tert-butyl-isoxazol-3-ylcarbamoyl)-5-oxo-pyrrolidin-1-yl]-phenyl}-methyl-carbamic acid tert-butyl ester (550 mg, 1.21 mmol) in dichloromethane (5 mL) is cooled in an ice bath. A pre-cooled trifluoroacetic acid (15 mL) is added and the mixture is kept in ice-bath for 30 minutes. Trifluoroacetic acid is evaporated in vacuo, and the residue is treated with ice and sodium bicarbonate solution. Extracted with ethyl acetate (1×150 mL) and the combined extracts washed with brine (50 mL) dried over anhydrous Na2SO4 and solvent removed in vacuo to give the title compound, ESI m/z 357 [M+H]+.

Provenance & Evidence