Trifluoroacetic acid → HCID 67464210, compound

Participants

Reaction Steps

(2S,4R)-4-tert-Butoxy-1-(4-chloro-phenyl)-pyrrolidine-2-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide (45 mg, 0.107 mmol) is dissolved in trifluoroacetic acid (0.5 mL, 6.49 mmol) at room temperature and the reaction is stirred at room temperature for 1 hour. The reaction is concentrated under reduced pressure and purification by chromatography on silica eluting with ethyl acetate/hexanes provides the title compound. ESI m/z 364 [M+H+].

Provenance & Evidence