HCID 86666037, compound → HCID 67953269, compound

Participants

Reaction Steps

10% Pd/C (40 mg) is added to a solution of (2S,4R)-1-(2-chloro-pyrimidin-4-yl)-4-hydroxy-pyrrolidine-2-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide (100 mg, 0.273 mmol) in ethanol (2 mL). The reaction is stirred under hydrogen atmosphere overnight at room temperature. The reaction is filtered through Celite® and the filtrate is concentrated. Purification by pre-HPLC eluting with 4-45% acetonitrile/water provides the title compound. ESI m/z 332 [M+H+].

Provenance & Evidence