Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 67953418, compound

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Reaction Conditions

Reaction Steps

(S)-5-Oxo-1-(4-trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid {3-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-isoxazol-5-yl}-amide is synthesized in a similar manner as Example 16, Method 7. (S)-5-Oxo-1-(4-trifluoromethyl-phenyl)-pyrrolidine-2-carboxylic acid {3-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-isoxazol-5-yl}-amide (0.546 g; 1.103 mmol) is dissolved in 2 mL ethanol and pyridinium p-toluenesulfonate (0.055 g; 0.221 mmol) is added. The mixture is heated at 55° C. for 4 h and then concentrated and purified by reverse phase HPLC to afford title compound. ESI m/z 412 [M+H]+

Provenance & Evidence