反应详情

5-Cyclohex-1-enyl-6-(2,2,2-trifluoroethoxy)nicotinic acid methylester (Example 2a, 163 mg, 517 μmmol) was dissolved in ethanol (5 mL). Palladium (10% on charcoal, 16.3 mg, 517 mmol) was added; the suspension was evacuated, flushed with hydrogen gas 3 times and stirred for 1.5 h at ambient temperature. The reaction mixture was filtered through Celite® and concentrated in vacuo to give the title compound (95 mg, quant.) as grey solid that was used in the subsequent reactions without further purification; MS (ESI) 318.1 (M+H)+.

1. customthe suspension was evacuated
2. customflushed with hydrogen gas 3 times
3. filtrationThe reaction mixture was filtered through Celite®
4. concentrationconcentrated in vacuo