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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 469774Generated: October 31, 2026

(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 5-Cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-N-(3-trifluoromethyl-[1,2,4]oxadiazol-5-ylmethyl)-nicotinamide

https://huagongshe.com/reaction/469774

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 55263061—
Reactant5-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acidHCID 71293952—
Product5-Cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-N-(3-trifluoromethyl-[1,2,4]oxadiazol-5-ylmethyl)-nicotinamideHCID 71528849—

Reaction Steps

The title compound was synthesized in analogy to Example 1b using 5-cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid (Example 4b) and C-(3-trifluoromethyl-1,2,4-oxadiazol-5-yl)-methylamine (CAN 944905-93-5) as starting materials; MS (ESI) 453.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08629166B2
Source datasetuspto-grants-2014_01
ORD IDord-44d315b3df544fbdbc28a2f663afce85
Source noteuspto-grants-2014_01