HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-5-isoxazolemethanamine → 5-cyclopentyl-N-(3-methoxy-isoxazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-5-isoxazolemethanamine | HCID 2763227 | — |
| Reactant | 5-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid | HCID 71294186 | — |
| Product | 5-cyclopentyl-N-(3-methoxy-isoxazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide | HCID 71294346 | — |
Reaction Steps
This compound was prepared following the same procedure as described in Example 11 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 9c) (135 mg, 0.47 mmol) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) (60.16 mg, 0.47 mmol) as starting materials; off white solid (59 mg, 37.8%). MS (ESI): 400 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629166B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-d01c956f79b342e2b0c1bd0683b15053 |
| Source note | uspto-grants-2014_01 |