HCID 66678705, compound → HCID 71294454, compound

HRID 469788Notes

Reaction equation

HRID 469788 reaction equation
[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([OH:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:22]1([CH2:25][N:26]2[CH:30]=[CH:29][C:28]([CH2:31][NH2:32])=[N:27]2)[CH2:24][CH2:23]1>>[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([NH:32][CH2:31][C:28]2[CH:29]=[CH:30][N:26]([CH2:25][CH:22]3[CH2:24][CH2:23]3)[N:27]=2)=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 66678705HCID 66678705, compoundHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 71294454HCID 71294454, compound

Procedure

This compound was prepared following the same procedure as described in Example 11 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 4b) (100 mg, 0.33 mmol) and C-(1-cyclopropylmethyl-1H-pyrazol-3-yl)-methylamine (51 mg, 0.33 mmol) as starting materials; off white solid (48 mg, 33.3%). MS (ESI): 437 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-27a05af8242842d28e81ff84fabe5b29
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

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