(2-Cyclopropylthiazol-4-yl)methanamine → 5-cyclohexyl-N-(2-cyclopropyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 469789Notes

Reaction equation

HRID 469789 reaction equation
[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([OH:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:22]1([C:25]2[S:26][CH:27]=[C:28]([CH2:30][NH2:31])[N:29]=2)[CH2:24][CH2:23]1>>[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([NH:31][CH2:30][C:28]2[N:29]=[C:25]([CH:22]3[CH2:24][CH2:23]3)[S:26][CH:27]=2)=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 45792629(2-Cyclopropylthiazol-4-yl)methanamineHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 712942565-cyclohexyl-N-(2-cyclopropyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

This compound was prepared following the same procedure as described in Example 11 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 4b) (100 mg, 0.33 mmol) and 2-cyclopropyl-4-thiazolemethanamine (CAN 1083299-53-9, 54 mg, 0.35 mmol) as starting materials; off white solid (66 mg, 45.4%). MS (ESI): 440 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-e27de2257d244278a2f179647a40447c
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

Loading…