HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridazine → 5-cyclohexyl-N-pyridazin-4-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridazine | HCID 298492 | — |
| Reactant | 5-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 71293952 | — |
| Product | 5-cyclohexyl-N-pyridazin-4-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide | HCID 71294298 | — |
Reaction Steps
This compound was prepared following the same procedure as described in Example 11 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 4b) (100 mg, 0.33 mmol) and 4-pyridazinamine (CAN 20744-39-2, 31.4 mg, 0.33 mmol) as starting materials; off white solid (60 mg, 47.8%). MS (ESI): 381.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629166B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-63f01adf23b44b20887b196c114af723 |
| Source note | uspto-grants-2014_01 |